Abstract
A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminopyridines / chemical synthesis*
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Aminopyridines / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Benzoxazoles / chemical synthesis*
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Benzoxazoles / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Computer Simulation
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Humans
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Models, Molecular
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Proto-Oncogene Proteins c-met / antagonists & inhibitors*
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Proto-Oncogene Proteins c-met / chemistry
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Structure-Activity Relationship
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fms-Like Tyrosine Kinase 3 / antagonists & inhibitors*
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fms-Like Tyrosine Kinase 3 / chemistry
Substances
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Aminopyridines
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Antineoplastic Agents
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Benzoxazoles
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FLT3 protein, human
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Proto-Oncogene Proteins c-met
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fms-Like Tyrosine Kinase 3